Setton Research Laboratory

Cartilage Mechanobiology

Gilchrist, CL, Chen, J, Richardson, WJ, Loeser, RF and Setton , LA (2007). Functional integrin subunits regulating cell-matrix interactions in the intervertebral disc. Journal of Orthopaedic Research. 25:829-40.

Gilchrist CL, Braam SW, Guilak F and Setton LA (2007). Measurement of intracellular strain on deformable substrates with texture correlation. Journal of Biomechanics 40:786-94.

Upton ML, Guilak F, Laursen TA, Setton LA (2006). Finite element modeling predictions of region-specific cell-matrix mechanics in the meniscus. Biomechanics and Modeling in Mechanobiology, DOI: 10.1007/s10237-006-0031-4.

Setton LA and Chen J (2006). Mechanobiology of the intervertebral disc and relevance to disc degeneration, Journal of Bone and Joint Surgery Am. 88 Suppl 1(Pt 2):52-7.

Upton ML, Hennerbichler A, Fermor B, Guilak F, Weinberg JB and Setton LA (2006). Biaxial strain effects on cells from the inner and outer regions of the meniscus. Connective Tissue Research 47(4):207-14.

Hyun J, Chen J, Setton LA and Chilkoti A (2006). Patterning cells in highly deformable microstructures: Effect of plastic deformation of substrate on cellular phenotype and gene expression. Biomaterials. 27:1444-51.

Chen J, Yan W and Setton LA (2006). Molecular phenotypes of notochordal cells purified from immature nucleus pulposus. European Spine Journal, Suppl 15:303-11.

Boyd LM, Richardson WJ, Chen J, Kraus VB, Tewari A and Setton LA (2005). Osmolarity regulates gene expression in intervertebral disc cells quantified with gene array and real-time quantitative RT-PCR. Annals of Biomedical Engineering, 33:8, 1071-1077.

Chen J, Yan W and Setton LA (2004). Static compression induces zonal-specific changes in gene expression for extracellular matrix and cytoskeletal proteins in intervertebral disc cells in vitro. Matrix Biology 22:573-583.

Upton ML, Chen J, Guilak F and Setton LA (2003). Differential effects of static and dynamic compression on meniscal cell gene expression. Journal of Orthopaedic Research 21:963-969.

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Tissue Engineering and Cartilage Repair

Lim DW, Nettles DL, Setton LA and Chilkoti A (2007). Rapid cross-linking of elastin-like polypeptides with (hydroxymethyl)phosphines in aqueous solution. Biomacromolecules 5:1463-70.

Betre H, Liu W, Zalutsky MR, Chilkoti A, Kraus VB and Setton LA (2006). A thermally responsive biopolymer for intra-articular drug delivery. J Controlled Release 115(2):175-82.

Betre H, Ong SR, Guilak F, Chilkoti A, Fermor B and Setton LA (2006). Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptides. Biomaterials 27:91-9.

Ong SR, Trabbic-Carlson KA, Nettles DL, Lim DW, Chilkoti A and Setton LA (2006). Epitope tagging for tracking elastin-like polypeptides. Biomaterials 27:1930-5.

McHale MK, Setton LA and Chilkoti A (2005): Synthesis and in vitro evaluation of enzymatically crosslinked elastin-like polypeptide gels for cartilaginous tissue repair. Tissue Engineering 11:1768-79.

Nettles DL, Vail TP, Morgan MT, Grinstaff MW, Setton LA (2004). Photocrosslinkable hyaluronan as a scaffold for articular cartilage repair. Annals of Biomedical Engineering 32:391-397.

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Cartilage Mechanics and Osteoarthritis

Cao L, Youn I, Guilak F and Setton LA (2006). Compressive properties of mouse articular cartilage determined in a novel micro-indentation test method and biphasic finite element model. Journal of Biomechanical Engineering 128(5):766-771.

Hu D, Xu L, Cao L, Flahiff CM, Setton LA, Youn I, Brussiau J, Ho K, Guilak F, Olsen BR, and Li Y (2006). Pathogenesis of osteoarthritis-like changes in joints of type IX collagen-deficient mice. Osteoarthritis & Cartilage 54(9):2891-2900.

Flahiff CM, Kraus VB, Huebner JL, Setton LA (2004). Cartilage mechanics in the guinea pig model of osteoarthritis studied with an osmotic loading method. Osteoarthritis & Cartilage 12:383-388.

Gilchrist CL, Xia JQ, Setton LA and Hsu EW (2004). High-resolution determination of soft tissue deformations using MRI and first-order texture correlation. IEEE Trans on Medical Imaging 23:546-553.

Kraus VB, Huebner JL, Stabler T, Flahiff CM, Setton LA, Fink C, Vilim V, Clark A (2004). Ascorbic acid increases the severity of spontaneous knee osteoarthritis in a guinea pig model. Arthritis & Rheumatism 50:1822-1831.

Xu L, Flahiff CM, Waldman BA, Wu D, Olsen BR, Setton LA, Li Y (2003). Osteoarthritis-like changes and decreased mechanical function of articular cartilage in the joints of mice with the chondrodysplasia gene (cho). Arthritis & Rheumatism 48:2509-2518.

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