Cartilage Mechanics and Tissue Engineering Laboratory

Lori A. Setton, Ph.D.

BME Department Pratt Duke Ortho

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Welcome to the Setton and Chen Laboratory

Research in the Laboratory is focused on understanding the mechanisms for degeneration and regeneration of soft tissues of the musculoskeletal system, including the intervertebral disc, articular cartilage, and meniscus.

Our research interests include:

  • Intervertebral Disc and Cartilage Tissue Engineering
  • Stem Cells for Regenerative Medicine
  • Drug Delivery
  • Cell and Extracellular Matrix Biomechanics
  • Animal Gait and Behavior in Models of Pain

News Brief

  • April 2013 - The laboratory welcomes Cooper Josiah Bowles, born to Rachel and Robby Bowles on April 30th! Weighing in at 5 lbs 1 oz, Cooper is doing great and already the new subject of his parents' photographic interests.

  • April 2013 - Tim Mwangi won this year's BEST POSTER AWARD in the Center for Cellular and Tissue Engineering Kewaunee Symposium. His poster, entitled, "Silk Near-Infrared Dye Particles For The Study Of Intra-articular Drug Delivery In Vivo" won in the Senior Student category. You make us proud, Tim!

  • April 2013 - Pricilla Hwang successfully presented her preliminary proposal and is on her way to the doctorate!

  • April 2013 - We had many presenters at this year's 2013 Osteoarthritis Research Society International Meeting in Philadelphia this month. David Tainter presented on the posterior tibial tendon in his collaboration with Dr. Adams, Michael Sinclair on his ELP-curcumin for attenuating neuroinflammation, Aubrey Francisco on her novel 3D hydrogels for injectable cell delivery, and Robby Bowles on his work with bioluminescence imaging of neuroinflammation in models of knee arthritis and sciatic nerve injury. It was a great meeting!

  • March 2013 - Dr. Setton was featured in the Biomedical Engineering Society Member Highlights! Go Dr. Setton!

  • March 2013 - Congratulations to Michael Sinclair on the successful defense of his thesis today! His doctoral work, entitled, "Development of Depot Forming Elastin-Like Polypeptide-Curcumin Drug Conjugates for Sustained Drug Delivery to Treat Neuroinflammatory Pathologies," was very well received by his committee! Now on to graduation in May!"

  • March 2013 - We're excited to learn that David Tainter, 3rd year medical student, has successfully and impressively passed his USMLE Step 1 examinations on his way to becoming a practicing clinician.



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