Cartilage Mechanics and Tissue Engineering Laboratory

Lori A. Setton, Ph.D.

BME Department Pratt Duke Ortho

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Welcome to the Setton and Chen Laboratory

Research in the Laboratory is focused on understanding the mechanisms for degeneration and regeneration of soft tissues of the musculoskeletal system, including the intervertebral disc, articular cartilage, and meniscus.

Our research interests include:

  • Intervertebral Disc and Cartilage Tissue Engineering
  • Stem Cells for Regenerative Medicine
  • Drug Delivery
  • Cell and Extracellular Matrix Biomechanics
  • Animal Gait and Behavior in Models of Pain

News Brief

  • March 2012 - Congratulations to new parents Michael and Jill Sinclair, on the birth of their daughter Evelyn Marie Sinclair, 8 lbs. 15.7 oz., and growing. We wish you all many happy days together!

  • March 2012 - We are proud to announce that two of our students are recipients of prestigious and competitive NSF Graduate Research Fellowships! Priscilla Hwang and Esther Lee will be supported by the NSF for their doctoral studies. Great work!

  • March 2012 - Congratulations to Priscilla Hwang, on the successful defense of her Master's thesis entitled, "Response of Midbrain Pain Receptors in a Rodent Model of Radiculopathy."

  • February 2012 - Kudos to Timothy Mwangi, doctoral student in BME, for receiving an outstanding score on his predoctoral fellowship application to the NIH. Tim has proposed a project entitled, "Silk Fibroin Small-Molecule Drug Carriers for the Treatment of Osteoarthritis." We wish Tim the best for a successful outcome.

  • November 2011 - The Laboratory presented a broad array of papers at this year's meeting of the North Carolina Tissue Engineering and Regenerative Medicine Society. Congratulations go to Timothy Mwangi, who won Best Poster Presentation for his work entitled, "Silk Fibroin Microparticles for Intra-articular Drug Delivery of Curcumin."

  • October 2011 - Laboratory members, Dovina Qu and Esther Lee, presented their research at the 2011 Annual Meeting of the BMES in Hartford this week. Dr. Robby Bowles presented work on engineering education that he studied while at Cornell, and Dr. Kyle Allen (Florida) presented on his work studying rodent gait in animal models performed while he was at Duke. Go to the Photos tab to see BMES 2011 photos.



  • Copyright © 2011 Lori Setton
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