Welcome to the Setton Laboratory
Research in the Laboratory is focused on understanding the mechanisms for degeneration and regeneration of soft tissues of the musculoskeletal system, including the intervertebral disc, articular cartilage, and meniscus.
Our research employs tools of mechanical engineering, synthetic chemistry, molecular biology, and analytic chemistry to advance use of drug depots and biomaterials to develop therapies for musculoskeletal pathology. Ongoing projects include:
- Synthesis of novel biomaterials for controlling intervertebral disc cell phenotype and metabolism
- Progenitor cell differentiation to intervertebral disc cell phenotypes
- Synthesis of novel drug depots for sustained release of inflammatory antagonists in arthritis and disc pathology
- Studies of cell-cell and cell-matrix interactions that regulate intervertebral disc and progenitor cell phenotypes
- Preclinical models of arthritis and intervertebral disc disorders and novel assessments of pain and dysfunction